Concise total synthesis of (±)-dasyscyphin D

Ling Zhang; Xingang Xie; Jian Liu; Jing Qi; Donghui Ma; Xuegong She

doi:10.1021/ol201047m

Concise total synthesis of (±)-dasyscyphin D

Org Lett. 2011 Jun 3;13(11):2956-8. doi: 10.1021/ol201047m. Epub 2011 May 11.

Authors

Ling Zhang¹, Xingang Xie, Jian Liu, Jing Qi, Donghui Ma, Xuegong She

Affiliation

¹ State Key Laboratory of Applied Organic Chemistry, Department of Chemistry, Lanzhou University, Lanzhou, People's Republic of China.

PMID: 21561088
DOI: 10.1021/ol201047m

Abstract

The first and efficient total synthesis of (±)-dasyscyphin D was achieved in 9 steps with 22.6% overall yield. The key steps involved a PtCl(2)-catalyzed pentannulation reaction and acid-catalyzed double Robinson annulations.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Catalysis
Diterpenes / chemical synthesis*
Diterpenes / chemistry
Molecular Structure
Platinum Compounds / chemistry
Stereoisomerism

Substances

Diterpenes
Platinum Compounds
dasyscyphin D
platinum chloride