Abstract
The amino acid and peptide derivatives of 1-adamantane carboxylic acid and rimantadine (18 compounds) have been first synthesized and investigated for their activity against influenza A virus (H1N1, H1N1v). In a series of obtained adamantine derivatives, some compounds have been found to be able to inhibit rimantadine-resistant influenza A virus strains. Thus, the antiviral properties of rimantadine can be restored.
MeSH terms
-
Adamantane / analogs & derivatives*
-
Adamantane / chemical synthesis
-
Adamantane / pharmacology
-
Adamantane / therapeutic use
-
Amantadine / analogs & derivatives
-
Amantadine / chemical synthesis
-
Amantadine / pharmacology
-
Amantadine / therapeutic use
-
Antiviral Agents / chemical synthesis
-
Antiviral Agents / pharmacology*
-
Antiviral Agents / therapeutic use
-
Drug Resistance, Viral / drug effects*
-
Humans
-
Influenza A Virus, H1N1 Subtype / drug effects*
-
Influenza, Human / drug therapy*
-
Rimantadine / analogs & derivatives
-
Rimantadine / chemical synthesis
-
Rimantadine / pharmacology*
-
Rimantadine / therapeutic use
Substances
-
Antiviral Agents
-
Rimantadine
-
adamantanecarboxylic acid
-
Amantadine
-
Adamantane