Risk stratification and short-term prognosis in acute heart failure syndromes: a review of novel biomarkers

Biomarkers. 2011 Aug;16(5):379-92. doi: 10.3109/1354750X.2011.574234. Epub 2011 May 2.

Abstract

Background: Early risk stratification of patients with acute heart failure syndrome (AHFS) can guide the decision to admit the patient to hospital and the choice of therapy.

Methods: Standard review methodology using Medline and Google scholar from the years 2006-present. Papers before 2006 were reviewed when necessary.

Results: Biomarkers used in AHFS are broadly classified based on their mechanism of action: inflammation, renal stress, extracellular matrix remodeling, oxidative stress, cardiac myocyte stress, and neurohormonal regulation.

Conclusion: This paper provides a review for clinicians and medical scientists highlighting the most recent advances in biomarkers with application in AHFS.

Publication types

  • Review

MeSH terms

  • Acute Disease
  • Biomarkers / metabolism*
  • Extracellular Matrix / metabolism
  • Heart Failure / metabolism*
  • Humans
  • Inflammation / metabolism
  • Kidney / metabolism
  • Kidney / physiopathology
  • Oxidative Stress
  • Prognosis
  • Stress, Physiological

Substances

  • Biomarkers