A vaccine prepared from a non-pathogenic H5N1 influenza virus strain from the influenza virus library conferred protective immunity to chickens against the challenge with antigenically drifted highly pathogenic avian influenza virus

Jpn J Vet Res. 2011 Feb;59(1):23-9.

Abstract

Inactivated influenza virus vaccine prepared from a non-pathogenic influenza virus strain A/duck/Hokkaido/Vac-1/2004 (H5N1) from the virus library conferred protective immunity to chickens against the challenge of antigenically drifted highly pathogenic avian influenza virus (HPAIV), A/whooper swan/Hokkaido/1/2008 (H5N1). The efficacy of the vaccine was comparable to that prepared from genetically modified HPAIV strain deltaRRRRK rg-A/ whooper swan/Mongolia/3/2005 (H5N1), which is more antigenically related to the challenge virus strain, in chickens.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anseriformes / immunology
  • Anseriformes / virology*
  • Antibodies, Viral / analysis
  • Antibodies, Viral / biosynthesis
  • Antibody Specificity
  • Chickens
  • Cross Reactions
  • DNA, Viral / genetics
  • Disease Outbreaks / prevention & control
  • Ducks / immunology
  • Ducks / virology*
  • Influenza A Virus, H5N1 Subtype / immunology
  • Influenza A Virus, H5N1 Subtype / physiology*
  • Influenza Vaccines / administration & dosage
  • Influenza Vaccines / genetics
  • Influenza Vaccines / immunology
  • Influenza in Birds / genetics
  • Influenza in Birds / immunology
  • Influenza in Birds / prevention & control*
  • Mongolia
  • Reassortant Viruses / growth & development
  • Reassortant Viruses / immunology*

Substances

  • Antibodies, Viral
  • DNA, Viral
  • Influenza Vaccines