Abstract
Squamous cell cervical carcinoma that metastasized to the ovary is common in patients with bulky tumors or locally advanced disease; however, ovarian squamous cell carcinoma that metastasized after cervical conization surgery for early microinvasive uterine cervical carcinoma is very rare. We present a case of ovarian squamous cell carcinoma that metastasized 8 years after cervical conization surgery for early microinvasive cervical carcinoma. She had no sign of recurrence in the uterine cervix. We detected human papillomavirus type 16 DNA in both cervical tissue and ovarian tissue, suggesting that ovarian squamous cell carcinoma is derived from microinvasive cervical cancer. Although there are very few cases of early microinvasive squamous cell carcinoma that metastasized to the ovary with delayed recurrence, we should pay attention strictly not only to the cervical condition but also to the ovarian condition on regular post-operative follow-up.
MeSH terms
-
Adult
-
Biomarkers, Tumor / analysis
-
Carboplatin / administration & dosage
-
Carcinoma, Squamous Cell / chemistry
-
Carcinoma, Squamous Cell / secondary*
-
Carcinoma, Squamous Cell / surgery*
-
Carcinoma, Squamous Cell / virology
-
Chemotherapy, Adjuvant
-
Conization*
-
Cyclin-Dependent Kinase Inhibitor p16
-
DNA, Viral / isolation & purification
-
Female
-
Humans
-
Immunohistochemistry
-
Neoplasm Invasiveness
-
Neoplasm Proteins / genetics
-
Neoplasm Proteins / isolation & purification*
-
Ovarian Neoplasms / chemistry
-
Ovarian Neoplasms / pathology*
-
Ovarian Neoplasms / surgery*
-
Ovarian Neoplasms / virology
-
Paclitaxel / administration & dosage
-
Palliative Care / methods*
-
Polymerase Chain Reaction
-
Pregnancy
-
Pregnancy Complications, Neoplastic / pathology*
-
Pregnancy Complications, Neoplastic / surgery*
-
Pregnancy Complications, Neoplastic / virology
-
Radiotherapy, Adjuvant
-
Reoperation
-
Time Factors
-
Uterine Cervical Neoplasms / pathology*
-
Uterine Cervical Neoplasms / surgery*
-
Uterine Cervical Neoplasms / virology
-
Watchful Waiting
Substances
-
Biomarkers, Tumor
-
CDKN2A protein, human
-
Cyclin-Dependent Kinase Inhibitor p16
-
DNA, Viral
-
Neoplasm Proteins
-
Carboplatin
-
Paclitaxel