Inhibition of histone demethylases by 4-carboxy-2,2'-bipyridyl compounds

ChemMedChem. 2011 May 2;6(5):759-764. doi: 10.1002/cmdc.201100026. Epub 2011 Mar 15.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 2,2'-Dipyridyl / chemical synthesis
  • 2,2'-Dipyridyl / chemistry*
  • 2,2'-Dipyridyl / pharmacology
  • Binding Sites
  • Computer Simulation
  • Crystallography, X-Ray
  • Enzyme Inhibitors / chemical synthesis
  • Enzyme Inhibitors / chemistry*
  • Enzyme Inhibitors / pharmacology
  • Humans
  • Jumonji Domain-Containing Histone Demethylases / antagonists & inhibitors*
  • Jumonji Domain-Containing Histone Demethylases / metabolism
  • Ketoglutaric Acids / chemistry
  • Protein Structure, Tertiary
  • Structure-Activity Relationship

Substances

  • Enzyme Inhibitors
  • Ketoglutaric Acids
  • 2,2'-Dipyridyl
  • Jumonji Domain-Containing Histone Demethylases
  • KDM4E protein, human

Associated data

  • PDB/3PDQ