Soy isoflavone equol perpetuates dextran sulfate sodium-induced acute colitis in mice

Biosci Biotechnol Biochem. 2011;75(3):593-5. doi: 10.1271/bbb.100710. Epub 2011 Mar 7.

Abstract

The effects of the soy isoflavones, genistein, daidzein and equol, on experimental colitis were examined. Equol severely perpetrated dextran sulfate sodium (DSS)-induced colitis as evaluated by the weight loss. Production of the anti-inflammatory cytokine, IL-10, from T cells was decreased in the equol-treated mice. The results show that the soy isoflavone, equol, played an important role in the inflammatory response in the gastrointestinal tract.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Body Weight / drug effects
  • Colitis / chemically induced
  • Colitis / immunology
  • Colitis / physiopathology
  • Dextran Sulfate / adverse effects
  • Disease Models, Animal
  • Equol
  • Female
  • Genistein / adverse effects
  • Genistein / pharmacology
  • Interleukin-10 / biosynthesis
  • Isoflavones / adverse effects*
  • Isoflavones / pharmacology
  • Mice
  • Mice, Inbred BALB C
  • T-Lymphocytes / drug effects
  • T-Lymphocytes / immunology

Substances

  • 4',7-dihydroxy-3,4-dihydroisoflavone
  • Isoflavones
  • Interleukin-10
  • Equol
  • daidzein
  • Dextran Sulfate
  • Genistein