A nanoscale DNA-Au dendrimer as a signal amplifier for the universal design of functional DNA-based SERS biosensors

Chem Commun (Camb). 2011 Apr 7;47(13):3840-2. doi: 10.1039/c0cc05133k. Epub 2011 Feb 14.

Abstract

The use of a nanoscale DNA-Au dendrimer as a signal amplifier was proposed for the universal design of functional DNA-based ultra-sensitive SERS biosensors. This novel design combines the high specificity of functional DNA with the high sensitivity of surface-enhanced Raman scattering (SERS) spectroscopy, resulting in sensitivity superior to that of previously reported sensors.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biosensing Techniques / methods*
  • DNA / chemistry*
  • Dendrimers / chemistry*
  • Gold / chemistry*
  • Lead / analysis*
  • Sensitivity and Specificity
  • Spectrum Analysis, Raman / methods*
  • Surface Properties

Substances

  • Dendrimers
  • Lead
  • Gold
  • DNA