3-amido-4-anilinocinnolines as a novel class of CSF-1R inhibitor

Bioorg Med Chem Lett. 2011 Mar 1;21(5):1382-4. doi: 10.1016/j.bmcl.2011.01.033. Epub 2011 Jan 14.

Abstract

3-Amido-4-anilinocinnolines have been identified as potent and highly selective inhibitors of CSF-1R. The synthesis and SAR of these compounds is reported, along with some physical property, pharmacokinetic and kinase selectivity data.

MeSH terms

  • Amides / chemical synthesis*
  • Amides / chemistry
  • Aniline Compounds / chemical synthesis*
  • Aniline Compounds / chemistry
  • Animals
  • Dogs
  • Heterocyclic Compounds, 2-Ring / chemical synthesis*
  • Heterocyclic Compounds, 2-Ring / chemistry
  • Mice
  • Molecular Structure
  • Protein Kinase Inhibitors / chemical synthesis*
  • Protein Kinase Inhibitors / chemistry
  • Rats
  • Receptor, Macrophage Colony-Stimulating Factor / antagonists & inhibitors*
  • Structure-Activity Relationship

Substances

  • Amides
  • Aniline Compounds
  • Heterocyclic Compounds, 2-Ring
  • Protein Kinase Inhibitors
  • Receptor, Macrophage Colony-Stimulating Factor
  • cinnoline
  • aniline