Abstract
A 65-year-old woman who had suffered from chronic graft-versus-host disease (GVHD) presented with extensive purpura and was diagnosed with acquired hemophilia A. Because she was refractory to corticosteroids and her condition was complicated with diabetes mellitus, glaucoma, and hypoglobulinemia, she was treated with tocilizumab. Tocilizumab treatment increased the activity of factor VIII in a rapid and sustained manner, leading to a reduction of the prednisolone dose. Tocilizumab may thus be an optional treatment modality for acquired hemophilia A.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Antibodies, Monoclonal, Humanized / administration & dosage
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Antibodies, Monoclonal, Humanized / therapeutic use*
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Drug Therapy, Combination
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Factor VIII / metabolism
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Female
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Glucocorticoids / administration & dosage
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Glucocorticoids / therapeutic use*
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Graft vs Host Disease / complications
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Graft vs Host Disease / drug therapy*
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Hemophilia A / complications
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Hemophilia A / drug therapy*
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Humans
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Prednisolone / administration & dosage
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Prednisolone / therapeutic use*
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Treatment Outcome
Substances
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Antibodies, Monoclonal, Humanized
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Glucocorticoids
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Factor VIII
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Prednisolone
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tocilizumab
Supplementary concepts
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Factor 8 deficiency, acquired