Dendritic cell-based immunotherapy for prostate cancer

Clin Dev Immunol. 2010:2010:517493. doi: 10.1155/2010/517493. Epub 2010 Nov 4.

Abstract

Dendritic cells (DCs) are professional antigen-presenting cells (APCs), which display an extraordinary capacity to induce, sustain, and regulate T-cell responses providing the opportunity of DC-based cancer vaccination strategies. Thus, clinical trials enrolling prostate cancer patients were conducted, which were based on the administration of DCs loaded with tumor-associated antigens. These clinical trials revealed that DC-based immunotherapeutic strategies represent safe and feasible concepts for the induction of immunological and clinical responses in prostate cancer patients. In this context, the administration of the vaccine sipuleucel-T consisting of autologous peripheral blood mononuclear cells including APCs, which were pre-exposed in vitro to the fusion protein PA2024, resulted in a prolonged overall survival among patients with metastatic castration-resistant prostate cancer. In April 2010, sipuleucel-T was approved by the United States Food and Drug Administration for prostate cancer therapy.

Publication types

  • Review

MeSH terms

  • Acid Phosphatase / immunology
  • Acid Phosphatase / metabolism
  • Animals
  • Antigen-Presenting Cells / immunology
  • Antigens, Neoplasm / immunology
  • Antigens, Neoplasm / metabolism
  • Cancer Vaccines*
  • Clinical Trials as Topic
  • Dendritic Cells / immunology*
  • Drug Approval
  • Granulocyte-Macrophage Colony-Stimulating Factor / immunology
  • Granulocyte-Macrophage Colony-Stimulating Factor / metabolism
  • Humans
  • Immunotherapy, Adoptive*
  • Lymphocyte Activation
  • Male
  • Prostatic Neoplasms / immunology*
  • Prostatic Neoplasms / pathology
  • Prostatic Neoplasms / therapy*
  • Recombinant Fusion Proteins / immunology
  • Recombinant Fusion Proteins / metabolism
  • Tissue Extracts / therapeutic use*
  • United States

Substances

  • Antigens, Neoplasm
  • Cancer Vaccines
  • Recombinant Fusion Proteins
  • Tissue Extracts
  • Granulocyte-Macrophage Colony-Stimulating Factor
  • sipuleucel-T
  • Acid Phosphatase
  • PA2024 fusion protein, human