Mn(0)-mediated chemoselective reduction of aldehydes. Application to the synthesis of α-deuterioalcohols

Tania Jiménez; Elisa Barea; J Enrique Oltra; Juan M Cuerva; José Justicia

doi:10.1021/jo1015618

Mn(0)-mediated chemoselective reduction of aldehydes. Application to the synthesis of α-deuterioalcohols

J Org Chem. 2010 Oct 15;75(20):7022-5. doi: 10.1021/jo1015618.

Authors

Tania Jiménez¹, Elisa Barea, J Enrique Oltra, Juan M Cuerva, José Justicia

Affiliation

¹ Department of Organic Chemistry, Faculty of Sciences, University ofGranada, C. U. Fuentenueva s/n, 18071 Granada, Spain.

PMID: 20845967
DOI: 10.1021/jo1015618

Abstract

A mild, simple, safe, chemoselective reduction of different kinds of aldehydes to the corresponding alcohols mediated by the Mn dust/water system is described. In addition to this, the use of D(2)O leads to the synthesis of α-deuterated alcohols and constitutes an efficient, inexpensive alternative for the preparation of these compounds.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alcohols / chemical synthesis*
Alcohols / chemistry
Aldehydes / chemistry*
Manganese / chemistry*
Molecular Structure
Oxidation-Reduction
Stereoisomerism

Substances

Alcohols
Aldehydes
Manganese