Design and synthesis of selective and potent orally active S1P5 agonists

ChemMedChem. 2010 Oct 4;5(10):1693-6. doi: 10.1002/cmdc.201000253.
No abstract available

MeSH terms

  • Administration, Oral
  • Amino Acid Sequence
  • Animals
  • Binding Sites
  • Computer Simulation
  • Drug Design
  • Fingolimod Hydrochloride
  • Molecular Sequence Data
  • Myelin Basic Protein / metabolism
  • Oligodendroglia / drug effects
  • Oligodendroglia / metabolism
  • Phthalazines / chemical synthesis
  • Phthalazines / chemistry*
  • Phthalazines / pharmacokinetics
  • Propylene Glycols / chemistry
  • Rats
  • Receptors, Lysosphingolipid / agonists*
  • Receptors, Lysosphingolipid / metabolism
  • Sphingosine / analogs & derivatives
  • Sphingosine / chemistry
  • Structure-Activity Relationship

Substances

  • Myelin Basic Protein
  • Phthalazines
  • Propylene Glycols
  • Receptors, Lysosphingolipid
  • phthalazine
  • Fingolimod Hydrochloride
  • Sphingosine