TCF-1 flips the switch on Eomes

Michael A Paley; E John Wherry

doi:10.1016/j.immuni.2010.08.008

TCF-1 flips the switch on Eomes

Immunity. 2010 Aug 27;33(2):145-7. doi: 10.1016/j.immuni.2010.08.008.

Authors

Michael A Paley¹, E John Wherry

Affiliation

¹ Department of Microbiology and Institute for Immunology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

PMID: 20732636
DOI: 10.1016/j.immuni.2010.08.008

Abstract

The interaction between different transcriptional pathways in CD8(+) T cell memory remains incompletely understood. In this issue, Zhou et al. (2010) demonstrate an important role for T cell factor 1 in regulating CD8(+) T cell memory via control of a second transcription factor, Eomesodermin.

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