Background and objective: Ambulatory chemotherapy has now been a popular way of treatment in developed countries, for its less medical costs and incidence of adverse events. The aim of this study is to estimate the feasibility and safety of ambulatory chemotherapy in lung cancer in Shanghai chest hospital.
Methods: Medical data including performance status, cycles of chemotherapy, pathologic type, adverse events in hospital and adverse events after discharge from hospital.
Results: We estimated a total of 1 573 lung cancer patients admitted in Shanghai chest hospital, during October 2008 to April 2009, including 416 patients treated in the way of ambulatory chemotherapy, 1 157 patients treated in the routine way. Rate of grade III/IV gastrointestinal toxicity was fewer in the ambulatory chemotherapy group (21.88%) than routine chemotherapy group (P < 0.01); meanwhile, rate of leukopenia was higher in the ambulatory chemotherapy group (49.28%) than routine chemotherapy group (35.0%)(P < 0.01). Days of hospitalization and medical costs were less in the ambulatory chemotherapy group (4.48 d vs 14.04 d, 6 911.32 vs 14 623.59, all P < 0.01).
Conclusions: Ambulatory chemotherapy is a favorable way to promote.
背景与目的: 日间化疗因具经济成本低、毒副反应不高的特点成为发达国家普遍采用的一种化疗模式，本文探讨上海市胸科医院日间化疗模式的可行性及安全性，为今后日间化疗模式的推广提供借鉴。
方法: 对所有入住日间化疗病房和普通化疗病房患者进行统计和记录，主要内容包括患者一般状况、化疗次数、病理类型、住院期间毒副反应、出院后出现的毒副反应。
结果: 2008年10月-2009年4月，我院日间病房共收治化疗患者416人次，普通病房共收治患者1 157人次，两组化疗的毒副反应总体差异不大，日间化疗患者的Ⅱ度以上胃肠道反应（21.88%）较住院患者低（38.89%）（P < 0.01），白细胞降低比例（49.28%）较住院患者（35.0%）为多（P < 0.01），日间化疗病房住院天数缩短（4.48天vs 14.04天，P < 0.01），医疗支出也大大降低（6 911.32元vs 14 623.59元，P < 0.01）。
结论: 日间化疗的住院时间和费用缩短，主要毒副反应为白细胞降低，化疗的累积毒性是其主要原因，需要引起注意，其它毒副反应未见明显差异，日间化疗是一种值得推广和借鉴的方式。