The stability of alpha-tocopheryl acetate and inherent tocopherols in swine grower diets containing high levels of trace minerals was studied in a 12-wk experiment. Corn-soybean meal diets with either 0 or 1% crude soybean oil and without trace minerals added (NOTM) were supplemented with a standard trace mineral mix (TM), TM + 250 ppm of Cu, TM + 1,000 ppm of Fe, TM + 1,000 ppm of Zn, or TM + 100 ppm of Mn. Alpha-tocopheryl acetate decreased linearly (P less than .0001) during 12 wk of storage in diets containing NOTM, TM, Zn, or Mn at a rate of .015 mg/d. Addition of Fe (P less than .005) or Cu (P less than .05) increased the rate of alpha-tocopheryl acetate loss. The addition of soybean oil had no effect (P greater than .1) on the rate of alpha-tocopheryl acetate loss. The alpha-tocopherol levels of the NOTM diet decreased (P less than .01) by approximately 50% during the 12-wk storage period. Addition of TM alone in diets that did not contain soybean oil had no effect P greater than .1) on the rate of alpha-tocopherol loss. The addition of Cu, Fe, Zn, or Mn (P less than .05) to diets that did not contain soybean oil increased the rate of alpha-tocopherol loss in comparison with NOTM and TM diets. Addition of Cu decreased alpha-tocopherol below 10% of initial levels in approximately 10 d. The addition of soybean oil to the diets containing TM, Fe, Zn (P less than .005), or Mn (P less than .05) further increased the rate of alpha-tocopherol loss.(ABSTRACT TRUNCATED AT 250 WORDS)