Nitrosation of malononitrile by HONO, ClNO and N₂O₃: a theoretical study

J Mol Model. 2011 May;17(5):1017-27. doi: 10.1007/s00894-010-0799-0. Epub 2010 Jul 22.

Abstract

Nitrosation reactions of malononitrile by three nitrosating agents, HONO, ClNO, and N(2)O(3), have been theoretically investigated at the B3LYP/cc-pVTZ and MP2/cc-pVDZ levels. Two possible competitive paths for nitrosation of malononitrile to give 2-nitroso-malononitrile were proposed: (a) direct C-nitrosation and (b) N-nitrosation and subsequent nitroso transfer from N to C atom. The calculations show that at both B3LYP and MP2 levels, path b is kinetically favored over path a for nitrosations by HONO and N(2)O(3). In the case of ClNO, the B3LYP predicts preference of path b, while the MP2 calculations suggest that both paths have similar rate-determining barriers. The data suggest that N(2)O(3) is the preferred nitrosating agent for the nitrosation of malononitrile in aqueous solution. Transformation of 2-nitroso-malononitrile to form malononitrileoxime via intramolecular proton transfer has also been explored, and it is found that inclusion of an assistant water molecule can drastically accelerate the tautomerization.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biological Products / chemistry
  • Isomerism
  • Models, Chemical
  • Models, Theoretical
  • Nitriles / chemistry*
  • Nitrogen Oxides / chemistry*
  • Nitrosation
  • Nitroso Compounds / chemistry*
  • Nitrous Acid / chemistry*
  • Protons*
  • Quantum Theory
  • Solutions
  • Thermodynamics
  • Water

Substances

  • Biological Products
  • Nitriles
  • Nitrogen Oxides
  • Nitroso Compounds
  • Protons
  • Solutions
  • Water
  • nitrogen trioxide
  • dicyanmethane
  • Nitrous Acid