Viral suppressors of RNA-based viral immunity: host targets

Cell Host Microbe. 2010 Jul 22;8(1):12-5. doi: 10.1016/j.chom.2010.06.009.

Abstract

RNA-based viral immunity (RVI) operates in fungi, plants, and invertebrates to specifically destroy viral RNAs using the cellular RNA interference machinery. Discovery of diverse viral proteins as suppressors of RNA silencing provides strong validation for the effectiveness of RVI. Here we review recent studies that have revealed new mechanistic insights into plant and insect viral suppressors of RVI or suggested a role for RNA silencing suppression during mammalian viral infection.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Host-Pathogen Interactions*
  • Humans
  • Plant Diseases / immunology*
  • Plant Diseases / virology
  • RNA Interference*
  • Viral Proteins / genetics
  • Viral Proteins / immunology*
  • Virus Diseases / immunology*
  • Virus Diseases / virology
  • Viruses / genetics
  • Viruses / immunology*

Substances

  • Viral Proteins