Premature ovarian failure (POF) is a heterogeneous group of disorders with amenorrhea and high serum gonadotropins in women of less than 40 years. Ovarian dysgenesis (OD) which is characterised by the loss of follicles before puberty describes the most severe POF outcome. Although a multitude of different factors including non-genetic as well as genetic causes are known to play a role in the development of POF and OD, the underlying etiology remains unsolved in the majority of cases. In the last years, array-CGH was found to be a very useful tool in the identification of candidate genes in different conditions. Therefore, we performed array-CGH analysis by using high-resolution Agilent oligonucleotide arrays in a total of 74 POF and OD patients and identified 44 private losses and gains potentially causative for POF. It is striking to note that a lot of the genes involved in these rearrangements can be classified in (i) genes involved in meiosis (e.g. PLCB1, RB1CC1, MAP4K4), (ii) genes involved in DNA repair (e.g. RBBP8) and (iii) genes involved in folliculogenesis or male fertility in homologs of model organisms (e.g. IMMP2L, FER1L6, MEIG1).