Effect of diltiazem, nifedipine and verapamil on the antinociceptive action of acetylsalicylic acid in mice

Gen Pharmacol. 1991;22(1):121-5. doi: 10.1016/0306-3623(91)90321-v.

Abstract

1. Diltiazem, verapamil and nifedipine produced a dose-dependent analgesic response in mice. 2. A fixed oral dose of acetylsalicylic acid increased this analgesic response. 3. Analgesia was maintained when mice were treated chronically with calcium channel blockers alone or when combined with aspirin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analgesics*
  • Animals
  • Aspirin / pharmacology*
  • Benzoquinones
  • Diltiazem / pharmacology*
  • Drug Interactions
  • Male
  • Mice
  • Nifedipine / pharmacology*
  • Pain / chemically induced
  • Pain / prevention & control
  • Reaction Time / drug effects
  • Verapamil / pharmacology*

Substances

  • Analgesics
  • Benzoquinones
  • phenylbenzoquinone
  • Verapamil
  • Diltiazem
  • Nifedipine
  • Aspirin