Insulators and promoters: closer than we think

Nat Rev Genet. 2010 Jun;11(6):439-46. doi: 10.1038/nrg2765. Epub 2010 May 5.

Abstract

Insulators prevent promiscuous gene regulation by restricting the action of enhancers and silencers. Recent studies have revealed a number of similarities between insulators and promoters, including binding of specific transcription factors, chromatin-modification signatures and localization to specific subnuclear positions. We propose that enhancer-blockers and silencing barrier-insulators might have evolved as specialized derivatives of promoters and that the two types of element use related mechanisms to mediate their distinct functions. These insights can help to reconcile different models of insulator action.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Chromosome Mapping
  • Enhancer Elements, Genetic / genetics
  • Enhancer Elements, Genetic / physiology
  • Evolution, Molecular*
  • Gene Expression Regulation / genetics*
  • Humans
  • Insulator Elements / genetics
  • Insulator Elements / physiology*
  • Models, Biological
  • Models, Genetic
  • Promoter Regions, Genetic / genetics
  • Promoter Regions, Genetic / physiology*
  • Transcription Factors / metabolism
  • Transcription Factors / physiology

Substances

  • Transcription Factors