Collagenous myofibroblastic tumor of the mandible: case report of a unique locally aggressive neoplasm

Head Neck Pathol. 2010 Mar;4(1):44-8. doi: 10.1007/s12105-009-0154-x. Epub 2009 Dec 10.

Abstract

We report a locally aggressive collagenous myofibroblastic neoplasm of the mandible in an 18-year-old male. Clinically, the lesion presented with rapid growth and irregular mandibular bone destruction. Grossly, the tumor was 10 cm in greatest dimension, light-tan, firm, and involving the posterior one-thirds of the body and inferior half of the left mandibular ramus. Histologically, the lesion was composed of a loose spindle cell proliferation interspersed with periodic dense bands of collagen. The spindle cells reacted positively to smooth muscle actin, calponin, and focally to desmin and were negative for S-100, pan-cytokeratin, CD99, CD34 and caldesmon, supporting myofibroblastic derivation. At our 4 year follow-up, the patient remained free of local recurrence and surgery related complications. The clinicopathologic findings and the differential diagnosis of this lesion is presented and discussed.

Publication types

  • Case Reports

MeSH terms

  • Actins / metabolism
  • Adolescent
  • Biomarkers, Tumor / metabolism
  • Biopsy, Fine-Needle
  • Calcium-Binding Proteins / metabolism
  • Calponins
  • Collagen / metabolism*
  • Desmin / metabolism
  • Humans
  • Immunohistochemistry
  • Male
  • Mandible / metabolism
  • Mandible / pathology
  • Mandible / surgery
  • Mandibular Neoplasms / metabolism
  • Mandibular Neoplasms / pathology*
  • Mandibular Neoplasms / surgery
  • Microfilament Proteins / metabolism
  • Mouth Mucosa / metabolism
  • Mouth Mucosa / pathology
  • Neoplasms, Muscle Tissue / metabolism
  • Neoplasms, Muscle Tissue / pathology*
  • Neoplasms, Muscle Tissue / surgery
  • Tomography, X-Ray Computed
  • Treatment Outcome

Substances

  • Actins
  • Biomarkers, Tumor
  • Calcium-Binding Proteins
  • Desmin
  • Microfilament Proteins
  • Collagen