Abstract
Fourteen Enterobacteriaceae isolates with ertapenem MIC >2 mg/mL were analyzed to identify mechanisms of resistance. All isolates produced extended-spectrum beta-lactamase or AmpC beta-lactamase with variable, but decreased, expression of outer membrane proteins. One Enterobacter cloacae produced derepressed AmpC beta-lactamase, 1 Escherichia coli expressed plasmid-mediated AmpC beta-lactamase, and 1 E. cloacae produced a carbapenemase.
Published by Elsevier Inc.
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Bacterial Outer Membrane Proteins / biosynthesis
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Bacterial Proteins / biosynthesis
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Enterobacteriaceae / drug effects*
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Enterobacteriaceae / isolation & purification
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Enterobacteriaceae Infections / microbiology*
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Ertapenem
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Humans
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Microbial Sensitivity Tests
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Plasmids
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Texas
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beta-Lactam Resistance*
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beta-Lactamases / biosynthesis*
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beta-Lactams / pharmacology*
Substances
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Anti-Bacterial Agents
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Bacterial Outer Membrane Proteins
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Bacterial Proteins
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beta-Lactams
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beta-Lactamases
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Ertapenem