Abstract
The first fully sequenced papillomavirus (PV) of marsupials, tentatively named Bettongia penicillata papillomavirus type 1 (BpPV1), was detected in papillomas from a woylie (Bettongia penicillata ogilbyi). The circular, double-stranded DNA genome contains 7,737 bp and encodes 7 open reading frames (ORFs), E6, E7, E1, E2, E4, L2, and L1, in typical PV conformation. BpPV1 is a close-to-root PV with L1 and L2 ORFs most similar to European hedgehog PV and bandicoot papillomatosis carcinomatosis virus types 1 and 2 (BPCV1 and -2). It appears that the BPCVs arose by recombination between an ancient PV and an ancient polyomavirus more than 10 million years ago.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Base Sequence
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Cluster Analysis
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DNA / genetics
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DNA, Circular / genetics
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DNA, Viral / chemistry
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DNA, Viral / genetics*
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Genome, Viral*
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Male
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Molecular Sequence Data
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Open Reading Frames
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Papilloma / veterinary*
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Papilloma / virology
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Phylogeny
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Polyomavirus / genetics*
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Polyomavirus / isolation & purification
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Polyomavirus Infections / veterinary*
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Polyomavirus Infections / virology
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Potoroidae / virology*
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Sequence Alignment
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Sequence Analysis, DNA
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Sequence Homology
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Tumor Virus Infections / veterinary*
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Tumor Virus Infections / virology
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Viral Proteins / genetics
Substances
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DNA, Circular
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DNA, Viral
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Viral Proteins
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DNA