New reduction pathways for ctc-[PtCl2(CH3CO2)2(NH3)(Am)] anticancer prodrugs

Chem Commun (Camb). 2010 Mar 21;46(11):1842-4. doi: 10.1039/b925721g. Epub 2010 Feb 12.

Abstract

Reduction of anticancer prodrugs such as ctc-[PtCl(2)(CH(3)CO(2))(2)(NH(3))(Am)] can yield three products in addition to the expected cis-[PtCl(2)(NH(3))(Am)]. A possible explanation is that reduction proceeds by several pathways where in addition to the loss of two axial ligands, one axial (acetato) and one equatorial (chlorido) ligand, or two equatorial ligands are eliminated.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / pharmacology
  • Organoplatinum Compounds / chemistry*
  • Oxidation-Reduction
  • Prodrugs / chemistry*
  • Prodrugs / pharmacology
  • X-Ray Absorption Spectroscopy

Substances

  • Antineoplastic Agents
  • Organoplatinum Compounds
  • Prodrugs