Use of normal tissue complication probability models in the clinic

Lawrence B Marks; Ellen D Yorke; Andrew Jackson; Randall K Ten Haken; Louis S Constine; Avraham Eisbruch; Søren M Bentzen; Jiho Nam; Joseph O Deasy

doi:10.1016/j.ijrobp.2009.07.1754

Use of normal tissue complication probability models in the clinic

Int J Radiat Oncol Biol Phys. 2010 Mar 1;76(3 Suppl):S10-9. doi: 10.1016/j.ijrobp.2009.07.1754.

Authors

Lawrence B Marks¹, Ellen D Yorke, Andrew Jackson, Randall K Ten Haken, Louis S Constine, Avraham Eisbruch, Søren M Bentzen, Jiho Nam, Joseph O Deasy

Affiliation

¹ Department of Radiation Oncology, University of North Carolina, Chapel Hill, NC 27514, USA. marks@med.unc.edu

Abstract

The Quantitative Analysis of Normal Tissue Effects in the Clinic (QUANTEC) review summarizes the currently available three-dimensional dose/volume/outcome data to update and refine the normal tissue dose/volume tolerance guidelines provided by the classic Emami et al. paper published in 1991. A "clinician's view" on using the QUANTEC information in a responsible manner is presented along with a description of the most commonly used normal tissue complication probability (NTCP) models. A summary of organ-specific dose/volume/outcome data, based on the QUANTEC reviews, is included.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Child
Dose Fractionation, Radiation
Dose-Response Relationship, Radiation
Humans
Models, Biological*
Models, Statistical*
Organ Specificity
Practice Guidelines as Topic*
Radiation Injuries / prevention & control*
Radiation Oncology*
Radiation Tolerance

Abstract

Publication types

MeSH terms

Grants and funding