Isoform specific functions of Nox protein-derived reactive oxygen species in the vasculature

Curr Opin Pharmacol. 2010 Apr;10(2):122-6. doi: 10.1016/j.coph.2010.01.002. Epub 2010 Feb 10.

Abstract

The family of NADPH oxidases consists of seven members that are all producing reactive oxygen species (ROS). In the cardiovascular systems three NADPH oxidases are expressed: Nox1, Nox2 and Nox4, which all exhibit different physiological functions such as regulating blood pressure, mediating growth factor signaling and controlling cell proliferation. In this article the recent research concerning the specificity and function mediated by NADPH oxidases will be reviewed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cardiovascular System / metabolism*
  • Endothelial Cells / metabolism
  • Humans
  • Isoenzymes / metabolism
  • Membrane Glycoproteins / metabolism
  • Models, Biological
  • Muscle, Smooth, Vascular / metabolism
  • NADPH Oxidase 1
  • NADPH Oxidase 2
  • NADPH Oxidase 4
  • NADPH Oxidases / metabolism*
  • Reactive Oxygen Species / metabolism*
  • Tissue Distribution

Substances

  • Isoenzymes
  • Membrane Glycoproteins
  • Reactive Oxygen Species
  • CYBB protein, human
  • NADPH Oxidase 1
  • NADPH Oxidase 2
  • NADPH Oxidase 4
  • NADPH Oxidases
  • NOX1 protein, human
  • NOX4 protein, human