acroglobulinemia, AL amyloidosis and the POEMS syndrome. The hematologist must characterize the hematological disorder, evaluate the need for treatment, and choose the best treatment option. The neurologist must define the type of neuropathy and evaluate the relationship between the abnormal immunoglobulin and the peripheral neuropathy. Thus, close co-operation between the hematologist and neurologist is necessary when a patient presents with both monoclonal immunoglobulin and peripheral neuropathy.