Abstract
We evaluated a novel psoralen-inactivated dengue virus type 1 (DENV-1) vaccine candidate in Mus musculus mice. Mice received intradermal alum or 5 to 10 ng of psoralen-inactivated virus. Anti-DENV-1 neutralizing antibody was detectable in 10/11 mice receiving a 10-ng dose at 90 days. Psoralen-inactivated DENV-1 is immunogenic in mice.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adjuvants, Immunologic / administration & dosage
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Alum Compounds / administration & dosage
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Animals
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Anti-Infective Agents / pharmacology*
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Antibodies, Neutralizing / blood
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Antibodies, Viral / blood
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Dengue Vaccines / administration & dosage
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Dengue Vaccines / immunology*
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Dengue Virus / drug effects*
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Dengue Virus / immunology*
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Ficusin / pharmacology*
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Injections, Intradermal
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Mice
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Vaccines, Inactivated / administration & dosage
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Vaccines, Inactivated / immunology
Substances
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Adjuvants, Immunologic
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Alum Compounds
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Anti-Infective Agents
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Antibodies, Neutralizing
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Antibodies, Viral
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Dengue Vaccines
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Vaccines, Inactivated
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aluminum sulfate
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Ficusin