A tangled web of ubiquitin chains: breaking news in TNF-R1 signaling

Mol Cell. 2009 Dec 11;36(5):736-42. doi: 10.1016/j.molcel.2009.11.029.

Abstract

A flurry of recent revelations is challenging the current dogma on how ubiquitin-dependent processes culminate in the activation of NF-kappaB by TNF. Here, we integrate these findings into a model for TNF-R1 signaling-and underscore the importance of individual components, including linear ubiquitin chains-which allows for the remarkable versatility of the ubiquitin system.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Models, Biological*
  • NF-kappa B / metabolism
  • Receptors, Tumor Necrosis Factor, Type I / metabolism*
  • Signal Transduction*
  • Tumor Necrosis Factor-alpha / metabolism
  • Ubiquitin / metabolism*
  • Ubiquitin / physiology

Substances

  • NF-kappa B
  • Receptors, Tumor Necrosis Factor, Type I
  • Tumor Necrosis Factor-alpha
  • Ubiquitin