Surveillance of transmitted resistance to antiretroviral drug classes among young children in the Western Cape Province of South Africa

Pediatr Infect Dis J. 2010 Apr;29(4):370-1. doi: 10.1097/INF.0b013e3181c4dada.

Abstract

There are limited data on transmitted antiretroviral resistance in young children who require antiretroviral therapy. We adapted the World Health Organization surveillance strategy, testing antiretroviral naive infants (<18 months) in the Western Cape Province of South Africa, and detecting only 3 non-nucleoside reverse transcriptase inhibitors (NNRTI) and no NRTI or protease inhibitor surveillance mutations in 49 patients. The estimated NRTI and protease inhibitor transmitted antiretroviral resistance prevalence is low (<5%), predicting good therapeutic response in Western Cape infants.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-HIV Agents / pharmacology*
  • Drug Resistance, Viral / genetics*
  • HIV Infections* / drug therapy
  • HIV Infections* / epidemiology
  • HIV Infections* / transmission
  • HIV Infections* / virology
  • HIV-1 / drug effects*
  • HIV-1 / enzymology
  • HIV-1 / genetics
  • Humans
  • Infant
  • Mutation*
  • Population Surveillance / methods
  • Prevalence
  • Reverse Transcriptase Inhibitors / pharmacology*
  • South Africa / epidemiology
  • World Health Organization

Substances

  • Anti-HIV Agents
  • Reverse Transcriptase Inhibitors