Damage to the perforating branches arising from the anterior communicating artery, because of their blood supply to the septal nuclei and anterior hypothalamus, explains the memory impairment and the electrolyte disturbances that often follow the surgery of aneurysms located in this part of the circle of Willis. The microsurgical anatomy of these branches was studied on 60 fixed human brains, with special attention to their number, caliber, and vascular territory. The direction of the branches was evaluated, measuring the angle formed by them with the postcommunicating segment of the anterior cerebral artery. The variability of this anatomical region is discussed in light of the literature.