Transient iatrogenic immunodeficiency-related B-cell lymphoproliferative disorder of the skin in a patient with mycosis fungoides/Sézary syndrome

J Cutan Pathol. 2011 Mar;38(3):295-7. doi: 10.1111/j.1600-0560.2009.01459.x.

Abstract

Immunodeficiency-related lymphoproliferative disorders (IR-LPD) may occur in the setting of immunosuppressive therapy with methotrexate and TNF-α antagonists. As far as we are aware, this is the first report of an Epstein-Barr virus-associated B-cell lymphoproliferative disorder, secondary to methotrexate therapy in a patient with mycosis fungoides/Sézary syndrome.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Azathioprine / therapeutic use
  • B-Lymphocytes / pathology
  • Epstein-Barr Virus Infections / complications
  • Humans
  • Immunocompromised Host*
  • Immunosuppressive Agents / therapeutic use
  • Lymphoproliferative Disorders / complications
  • Lymphoproliferative Disorders / immunology*
  • Lymphoproliferative Disorders / virology
  • Male
  • Methotrexate / therapeutic use
  • Mycosis Fungoides / complications*
  • Mycosis Fungoides / drug therapy
  • Prednisone / therapeutic use
  • Sezary Syndrome / complications*
  • Sezary Syndrome / drug therapy
  • Skin Neoplasms / complications*
  • Skin Neoplasms / drug therapy

Substances

  • Immunosuppressive Agents
  • Azathioprine
  • Prednisone
  • Methotrexate