Mst out and HCC in

Bin Zhao; Qunying Lei; Kun-Liang Guan

doi:10.1016/j.ccr.2009.10.008

Mst out and HCC in

Cancer Cell. 2009 Nov 6;16(5):363-4. doi: 10.1016/j.ccr.2009.10.008.

Authors

Bin Zhao¹, Qunying Lei, Kun-Liang Guan

Affiliation

¹ Department of Pharmacology and Moores Cancer Center, University of California at San Diego, La Jolla, CA 92093-0815, USA.

PMID: 19878866
DOI: 10.1016/j.ccr.2009.10.008

Abstract

Mst1 and Mst2 are key components of the Hippo tumor suppressor pathway. In this issue, Zhou et al. (2009) reported that Mst1/2 ablation leads to hepatocellular carcinomas. Unexpectedly, Mst1/2 may activate another kinase besides Lats1 and Lats2 to phosphorylate YAP, and the role of Mst1/2 in YAP regulation is cell type dependent.

Publication types

Comment

MeSH terms

Animals
Liver Neoplasms, Experimental / enzymology*
Liver Neoplasms, Experimental / genetics
Mice
Mice, Knockout
Protein Serine-Threonine Kinases / deficiency*
Protein Serine-Threonine Kinases / genetics
Serine-Threonine Kinase 3

Substances

Stk4 protein, mouse
Protein Serine-Threonine Kinases
Serine-Threonine Kinase 3
Stk3 protein, mouse