Abstract
Recent studies suggest the potential interest of ribavirin therapeutic drug monitoring to improve sustain virological response rate in hepatitis C virus-infected patients. The present review details the pharmacokinetic properties of ribavirin, suggesting that it may be a good candidate for therapeutic drug monitoring, the different possible strategies and the analytical methods that could be employed.
MeSH terms
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Antiviral Agents* / administration & dosage
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Antiviral Agents* / blood
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Antiviral Agents* / therapeutic use
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Biological Availability
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Dose-Response Relationship, Drug
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Drug Monitoring / methods*
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Hepacivirus / drug effects*
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Hepacivirus / genetics
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Hepatitis C, Chronic / drug therapy
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Hepatitis C, Chronic / metabolism
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Hepatitis C, Chronic / virology
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Humans
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Ribavirin* / administration & dosage
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Ribavirin* / blood
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Ribavirin* / therapeutic use
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Viral Load
Substances
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Antiviral Agents
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Ribavirin