2-Hydroxydiplopterol, a new cytotoxic pentacyclic triterpenoid from the halotolerant fungus Aspergillus variecolor B-17

Wen-Liang Wang; Pei-Pei Liu; Ya-Peng Zhang; Jing Li; Hong-Wen Tao; Qian-Qun Gu; Wei-Ming Zhu

doi:10.1007/s12272-009-1904-8

2-Hydroxydiplopterol, a new cytotoxic pentacyclic triterpenoid from the halotolerant fungus Aspergillus variecolor B-17

Arch Pharm Res. 2009 Sep;32(9):1211-4. doi: 10.1007/s12272-009-1904-8. Epub 2009 Sep 26.

Authors

Wen-Liang Wang¹, Pei-Pei Liu, Ya-Peng Zhang, Jing Li, Hong-Wen Tao, Qian-Qun Gu, Wei-Ming Zhu

Affiliation

¹ Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.

PMID: 19784575
DOI: 10.1007/s12272-009-1904-8

Abstract

A new hopane type pentacyclic triterpenoid, 2-hydroxydiplopterol (1) has been isolated from the metabolites produced by the halotolerant fungal strain Aspergillus variecolor B-17. The structure of 1 was determined by spectroscopic methods and single crystal X-Ray diffraction analysis. 2-Hydroxydiplopterol (1) exhibited cytotoxicity against K562 cells with an IC50 value of 22 microM.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / chemistry*
Antineoplastic Agents / isolation & purification
Antineoplastic Agents / pharmacology
Aspergillus / metabolism*
Crystallography, X-Ray
Humans
K562 Cells
Leukemia P388 / drug therapy
Mice
Pentacyclic Triterpenes / chemistry*
Pentacyclic Triterpenes / isolation & purification
Pentacyclic Triterpenes / pharmacology

Substances

Antineoplastic Agents
Pentacyclic Triterpenes