Antibiotic resistance determinants in Acinetobacter spp and clinical outcomes in patients from a major military treatment facility

Am J Infect Control. 2010 Feb;38(1):63-5. doi: 10.1016/j.ajic.2009.05.007. Epub 2009 Sep 24.

Abstract

We explored the association of antibiotic-resistant phenotypes and genotypes in Acinetobacter spp with clinical outcomes and characteristics in 75 patients from a major military treatment facility. Amikacin resistance was associated with nosocomial acquisition of A baumannii, and carbapenem resistance and bla(OXA-23) were associated with the need for mechanical ventilation. The presence of bla(OXA-23) also correlated with longer hospital and ICU stay. Associations between bla(OXA-23) and complexity, duration, and changes made to antibiotic regimens also existed.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Acinetobacter / drug effects*
  • Acinetobacter / genetics
  • Acinetobacter / isolation & purification
  • Acinetobacter Infections / drug therapy*
  • Acinetobacter Infections / microbiology*
  • Anti-Bacterial Agents / pharmacology
  • Anti-Bacterial Agents / therapeutic use*
  • Bacterial Proteins / biosynthesis
  • Bacterial Proteins / genetics
  • DNA, Bacterial / genetics
  • Drug Resistance, Bacterial*
  • Genotype
  • Hospitals, Military
  • Humans
  • Length of Stay
  • Microbial Sensitivity Tests
  • Phenotype
  • Respiration, Artificial
  • Treatment Outcome
  • beta-Lactamases / biosynthesis
  • beta-Lactamases / genetics

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • DNA, Bacterial
  • beta-lactamase OXA-23
  • beta-Lactamases