Mastering the chemical language of bacteria

Chem Biol. 2009 Sep 25;16(9):913-4. doi: 10.1016/j.chembiol.2009.09.006.

Abstract

The publication of the crystal structures of a bacterial quorum sensing receptor complexed with a variety of ligands (Zou and Nair, 2009) provides a much-needed molecular rationale for the modulation of this intercellular signaling process, which may facilitate the development of new therapeutic agents.

Publication types

  • Comment

MeSH terms

  • 4-Butyrolactone / analogs & derivatives
  • 4-Butyrolactone / pharmacology
  • Bacterial Proteins / chemistry*
  • Bacterial Proteins / metabolism
  • Crystallography, X-Ray
  • Protein Binding
  • Pseudomonas aeruginosa / metabolism*
  • Quorum Sensing / physiology*
  • Small Molecule Libraries
  • Terphenyl Compounds / chemistry
  • Terphenyl Compounds / pharmacology*
  • Trans-Activators / chemistry*
  • Trans-Activators / metabolism

Substances

  • Bacterial Proteins
  • LasR protein, Pseudomonas aeruginosa
  • Small Molecule Libraries
  • Terphenyl Compounds
  • Trans-Activators
  • homoserine lactone
  • 4-Butyrolactone