Cascade synthesis of (E)-2-alkylidenecyclobutanols

J R Falck; Anish Bandyopadhyay; Narender Puli; Abhijit Kundu; L Manmohan Reddy; Deb K Barma; Anyu He; Hongming Zhang; Dhurke Kashinath; Rachid Baati

doi:10.1021/ol901985c

Cascade synthesis of (E)-2-alkylidenecyclobutanols

Org Lett. 2009 Oct 15;11(20):4764-6. doi: 10.1021/ol901985c.

Authors

J R Falck¹, Anish Bandyopadhyay, Narender Puli, Abhijit Kundu, L Manmohan Reddy, Deb K Barma, Anyu He, Hongming Zhang, Dhurke Kashinath, Rachid Baati

Affiliation

¹ Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA. j.falck@utsouthwestern.edu

Abstract

A facile, one-pot reaction cascade condenses 1,1,1-trichloroalkanes with alpha,beta-unsaturated ketones to unexpectedly furnish moderate to good yields of (E)-2-alkylidenecyclobutanols.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Cyclobutanes / chemical synthesis*
Cyclobutanes / chemistry*
Ketones / chemistry
Stereoisomerism

Substances

Cyclobutanes
Ketones
cyclobutanol

Abstract

Publication types

MeSH terms

Substances

Grants and funding