Detection of twelve nucleotides insertion in the BCR-ABL kinase domain in an imatinib-resistant but dasatinib-sensitive patient with bi-phenotypic acute leukemia

Haematologica. 2009 Sep;94(9):1324-6. doi: 10.3324/haematol.2009.007864.
No abstract available

Publication types

  • Case Reports
  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence / genetics*
  • Benzamides
  • Dasatinib
  • Drug Resistance, Neoplasm
  • Female
  • Fusion Proteins, bcr-abl / antagonists & inhibitors
  • Fusion Proteins, bcr-abl / genetics*
  • Fusion Proteins, bcr-abl / metabolism
  • Humans
  • Imatinib Mesylate
  • Leukemia, Biphenotypic, Acute / drug therapy
  • Leukemia, Biphenotypic, Acute / enzymology
  • Leukemia, Biphenotypic, Acute / genetics*
  • Middle Aged
  • Piperazines / administration & dosage*
  • Protein Kinase Inhibitors / administration & dosage*
  • Protein Structure, Tertiary / genetics
  • Protein-Tyrosine Kinases / antagonists & inhibitors
  • Protein-Tyrosine Kinases / genetics*
  • Protein-Tyrosine Kinases / metabolism
  • Pyrimidines / administration & dosage*
  • Sequence Deletion*
  • Thiazoles / administration & dosage*

Substances

  • Benzamides
  • Piperazines
  • Protein Kinase Inhibitors
  • Pyrimidines
  • Thiazoles
  • Imatinib Mesylate
  • Protein-Tyrosine Kinases
  • Fusion Proteins, bcr-abl
  • Dasatinib