The Heidelberg Retina Tomograph (HRT) is a glaucoma diagnosis system that provides fast, noninvasive topographic information about the optic nerve head, the neuroretinal rim, and the thickness of the nerve fiber layer. With these capabilities, it is one of the leading laser systems for detecting glaucoma. Statistical methods such as the Moorfields regression analysis and the glaucoma probability score, as well as discriminant functions implemented in the instrument, support the clinician in discriminating between glaucoma and healthy eyes. The primary method for assessing glaucomatous change using the HRT is topographic change analysis, a technique that compares the variability within a baseline examination to that between baseline and follow-up examinations. The stereometric trend analysis reports changes in normalized topographic parameters over time. Furthermore, the flicker comparison enables the detection of small topographic changes over time. The use of HRT does not replace clinical examination but facilitates the assessment and management of glaucoma according to the observer's experience.