Linking amyloid and tau pathology in Alzheimer's disease: the role of membrane cholesterol in Abeta-mediated tau toxicity

J Neurosci. 2009 Aug 5;29(31):9665-7. doi: 10.1523/JNEUROSCI.2234-09.2009.
No abstract available

MeSH terms

  • Aging
  • Alzheimer Disease / diet therapy
  • Alzheimer Disease / physiopathology*
  • Amyloid beta-Peptides / metabolism*
  • Calcium / metabolism
  • Calpain / metabolism
  • Cell Death / drug effects
  • Cell Death / physiology
  • Cell Membrane / drug effects
  • Cell Membrane / metabolism*
  • Cholesterol / metabolism*
  • Hippocampus / drug effects
  • Hippocampus / physiopathology
  • Humans
  • Nerve Degeneration / drug therapy
  • Nerve Degeneration / physiopathology
  • Neurons / drug effects
  • Neurons / physiology
  • Signal Transduction
  • beta-Cyclodextrins / pharmacology
  • tau Proteins / metabolism*

Substances

  • Amyloid beta-Peptides
  • MAPT protein, human
  • beta-Cyclodextrins
  • methyl-beta-cyclodextrin
  • tau Proteins
  • Cholesterol
  • Calpain
  • Calcium