Effect of corticotropin-like intermediate lobe peptide on presynaptic and postsynaptic glutamate receptors and postsynaptic GABA receptors in rat brain

V V Grigoriev; L N Petrova; T A Ivanova; A V Gabreliyan; T P Serkova

doi:10.1007/s10517-009-0499-x

Effect of corticotropin-like intermediate lobe peptide on presynaptic and postsynaptic glutamate receptors and postsynaptic GABA receptors in rat brain

Bull Exp Biol Med. 2009 Mar;147(3):319-22. doi: 10.1007/s10517-009-0499-x.

Authors

V V Grigoriev¹, L N Petrova, T A Ivanova, A V Gabreliyan, T P Serkova

Affiliation

¹ Laboratory of Neurochemistry, Institute of Physiologically Active Substances, Russian Academy Sciences, Chernogolovka, Moscow Region, Russia. grigor@ipac.ac.ru

PMID: 19529852
DOI: 10.1007/s10517-009-0499-x

Abstract

We studied the effect of corticotropin-like intermediate lobe peptide (CLIP) on presynaptic NMDA receptors and postsynaptic GABA, NMDA, and AMPA receptors in rat brain. CLIP inhibited presynaptic and postsynaptic NMDA receptors, but potentiated postsynaptic GABA and AMPA receptors. Our results indicate that CLIP modulates function of ionotropic receptors for glutamate and GABA.

MeSH terms

Animals
Animals, Newborn
Corticotropin-Like Intermediate Lobe Peptide / pharmacology*
Patch-Clamp Techniques
Presynaptic Terminals / drug effects
Rats
Rats, Wistar
Receptors, AMPA / drug effects
Receptors, GABA / drug effects*
Receptors, Glutamate / drug effects*
Receptors, N-Methyl-D-Aspartate / drug effects
Synaptic Transmission / drug effects

Substances

Receptors, AMPA
Receptors, GABA
Receptors, Glutamate
Receptors, N-Methyl-D-Aspartate
Corticotropin-Like Intermediate Lobe Peptide