SNCA variants are associated with increased risk for multiple system atrophy

Ann Neurol. 2009 May;65(5):610-4. doi: 10.1002/ana.21685.

Abstract

To test whether the synucleinopathies Parkinson's disease and multiple system atrophy (MSA) share a common genetic etiology, we performed a candidate single nucleotide polymorphism (SNP) association study of the 384 most associated SNPs in a genome-wide association study of Parkinson's disease in 413 MSA cases and 3,974 control subjects. The 10 most significant SNPs were then replicated in additional 108 MSA cases and 537 controls. SNPs at the SNCA locus were significantly associated with risk for increased risk for the development of MSA (combined p = 5.5 x 10(-12); odds ratio 6.2) [corrected].

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease*
  • Genome-Wide Association Study / methods
  • Genotype
  • Humans
  • Male
  • Multiple System Atrophy / genetics*
  • Odds Ratio
  • Polymorphism, Single Nucleotide / genetics*
  • Risk
  • alpha-Synuclein / genetics*

Substances

  • SNCA protein, human
  • alpha-Synuclein