Novel ABC transporter gene, vga(C), located on a multiresistance plasmid from a porcine methicillin-resistant Staphylococcus aureus ST398 strain

Antimicrob Agents Chemother. 2009 Aug;53(8):3589-91. doi: 10.1128/AAC.00570-09. Epub 2009 May 26.

Abstract

A novel ABC transporter gene, vga(C), was identified on the 14,365-bp multiresistance plasmid pKKS825 in a porcine methicillin (meticillin)-resistant Staphylococcus aureus isolate of sequence type 398. The vga(C) gene encodes a 523-amino-acid protein which confers resistance not only to streptogramin A antibiotics but also to lincosamides and pleuromutilins. Plasmid pKKS825 also carries the resistance genes aadD, tet(L), and dfrK, which may enable the coselection of vga(C) under selective pressure by kanamycin/neomycin, tetracyclines, and trimethoprim.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • ATP-Binding Cassette Transporters / genetics*
  • Animals
  • Anti-Bacterial Agents / pharmacology*
  • Bacterial Proteins / genetics*
  • Diterpenes / pharmacology
  • Drug Resistance, Multiple, Bacterial / genetics*
  • Kanamycin / pharmacology
  • Lincosamides / pharmacology
  • Methicillin-Resistant Staphylococcus aureus* / drug effects
  • Methicillin-Resistant Staphylococcus aureus* / genetics
  • Molecular Sequence Data
  • Neomycin / pharmacology
  • Plasmids / genetics*
  • Pleuromutilins
  • Polycyclic Compounds
  • Staphylococcal Infections / microbiology*
  • Streptogramin A / pharmacology
  • Swine
  • Swine Diseases / microbiology*
  • Tetracyclines / pharmacology
  • Trimethoprim / pharmacology

Substances

  • ATP-Binding Cassette Transporters
  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Diterpenes
  • Lincosamides
  • Polycyclic Compounds
  • Tetracyclines
  • VgA protein, Staphylococcus aureus
  • Kanamycin
  • Streptogramin A
  • Trimethoprim
  • Neomycin

Associated data

  • GENBANK/FN377602