Abstract
Muscleblind-like 2 (Mbnl2) is a zinc finger protein first identified in Drosophila. It appears to be essential for photoreceptor development and to be involved in RNA splicing. Here we report that Mbnl2 is strongly expressed in the rat pineal gland. The abundance of pineal Mbnl2 transcripts follows a marked circadian rhythm with peak levels approximately sevenfold higher at night than day levels. Mbnl2 protein exhibits a similar rhythm. In vitro studies indicate that the abundance of Mbnl2 transcripts and protein are controlled by an adrenergic/cAMP mechanism.
Publication types
-
Comparative Study
-
Research Support, N.I.H., Intramural
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adrenergic Fibers / chemistry
-
Adrenergic Fibers / physiology
-
Animals
-
Cell Line
-
Circadian Rhythm* / genetics
-
Cyclic AMP / metabolism*
-
Female
-
Gene Expression Regulation / physiology*
-
Humans
-
Male
-
Neurons / chemistry
-
Neurons / physiology
-
Organ Culture Techniques
-
Pineal Gland / physiology*
-
RNA-Binding Proteins / biosynthesis*
-
RNA-Binding Proteins / genetics
-
Rabbits
-
Rats
-
Rats, Sprague-Dawley
Substances
-
Mbnl2 protein, mouse
-
RNA-Binding Proteins
-
Cyclic AMP