Intraosseous cavernous hemangioma is rarely located in the calvarium. This benign tumor, arising from the intrinsic vasculature of bone, grows slowly over a period of years before it causes symptoms such as headaches or localized compression. We report here the case of a 27-year-old man, who presented with multiple calvarial cavernous hemangiomas associated with several hepatic hemangiomas. The patient had a family history of the disease, and is only the second case of multiple calvarial cavernous hemangiomas reported in the literature. The clinical, radiological and therapeutic aspects of this rare entity are also discussed.