Abstract
Adjuvants are necessary to elicit high titers of antibodies in vaccine-immunization procedures. We previously developed a mouse tumor necrosis factor-alpha (TNF-alpha) autovaccine (mTNF-PADRE) capable of inducing anti-TNF-alpha antibodies. In this study, we investigated the therapeutic effect of adjuvant-free administration of the autovaccine on collagen-type-II-induced rheumatoid arthritis (CIA) in mice. Our results showed that the vaccine could ameliorate the symptoms of CIA in mice. In addition, this study suggests that it is possible to control the antibody levels in mice immunized with mTNF-PADRE without adjuvant.
MeSH terms
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Adjuvants, Immunologic
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Animals
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Ankle Joint / immunology
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Ankle Joint / pathology
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Antibody Formation / immunology
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Arthritis, Experimental / pathology
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Arthritis, Experimental / prevention & control
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Arthritis, Experimental / therapy*
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Autovaccines / administration & dosage*
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Autovaccines / immunology
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Collagen Type II / immunology
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Disease Models, Animal
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Knee Joint / immunology
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Knee Joint / pathology
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Male
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Mice
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Mice, Inbred BALB C
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Mice, Inbred DBA
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Tumor Necrosis Factor-alpha / administration & dosage
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Tumor Necrosis Factor-alpha / immunology*
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Tumor Necrosis Factor-alpha / metabolism
Substances
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Adjuvants, Immunologic
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Autovaccines
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Collagen Type II
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Tumor Necrosis Factor-alpha
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mTNF-PADRE