The incidence of postinfarction ventricular septal rupture is declining as coronary revascularization techniques have become available for a large number of patients. However, morbidity and mortality rates associated with this complication remain high. We report the case of a patient suffering from acute myocardial infarction who developed a postinfarction ventricular septal defect. Instead of attempting surgical closure, he was placed on biventricular mechanical support. After 2 weeks, surgical closure of the defect and concomitant explantation of the assist device were successfully performed. This approach may represent a new treatment option restoring hemodynamic stability and avoiding surgery on freshly infarcted myocardium.