The insulin receptor talks to glucagon?

Cell Metab. 2009 Apr;9(4):303-5. doi: 10.1016/j.cmet.2009.03.008.

Abstract

Type 2 diabetes (T2DM) is not only a disorder of impaired insulin secretion but also glucagon oversecretion. However, the link between the two remains unclear. Is it possible that the latter is a consequence of the former? In this issue, Kawamori et al. (2009) have addressed this question by generating alpha cell-specific insulin receptor knockout mice.

Publication types

  • Comment

MeSH terms

  • Animals
  • Glucagon / genetics
  • Glucagon / metabolism*
  • Glucagon-Secreting Cells / metabolism
  • Glucagon-Secreting Cells / pathology
  • Insulin / genetics
  • Insulin / metabolism
  • Insulin-Secreting Cells / metabolism
  • Insulin-Secreting Cells / pathology
  • Mice
  • Organ Specificity
  • Receptor, Insulin / deficiency
  • Receptor, Insulin / metabolism*
  • Signal Transduction

Substances

  • Insulin
  • Glucagon
  • Receptor, Insulin