Abstract
Type 2 diabetes (T2DM) is not only a disorder of impaired insulin secretion but also glucagon oversecretion. However, the link between the two remains unclear. Is it possible that the latter is a consequence of the former? In this issue, Kawamori et al. (2009) have addressed this question by generating alpha cell-specific insulin receptor knockout mice.
MeSH terms
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Animals
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Glucagon / genetics
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Glucagon / metabolism*
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Glucagon-Secreting Cells / metabolism
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Glucagon-Secreting Cells / pathology
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Insulin / genetics
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Insulin / metabolism
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Insulin-Secreting Cells / metabolism
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Insulin-Secreting Cells / pathology
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Mice
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Organ Specificity
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Receptor, Insulin / deficiency
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Receptor, Insulin / metabolism*
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Signal Transduction
Substances
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Insulin
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Glucagon
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Receptor, Insulin